報告人：姚成貴

報告題目：Theoretical Modeling of Dynamic Transitions Among Wakefulness, NREM, and REM Sleep in Healthy Sleep Cycles

報告時間：2025年9月20日（周六）下午5：00    

報告地點：物理與電子工程學院428會議室        

主辦單位：物理與電子工程學院、科學技術研究院      

報告人簡介：

姚成貴博士，嘉興大學教授。入選浙江省高校領軍人才培養計劃高層次拔尖人才，浙江省高校中青年學科帶頭人。2011年于中科院武漢物理與數學研究所獲得理學博士學位。主要研究方向：睡眠動力學，非線性動力學，神經動力學及其數學建模。目前發表SCI論文50余篇，主持完成國家自然科學基金面上項目，主持完成國家自然科學基金青年基金項目，浙江省自然科學基金面上項目，中國博士后基金。

報告摘要：

We present a physiologically grounded mean-field model of sleep-wake regulation that unifies wakefulness,  NREM ,andREM sleep within a single dynamical framework.Extending the Action-Arousal  architecture, we explicitly incorporate wakefulness-specific populations (Action and Arousal) alongside NREM and REM populations, and we embed circadian, ultradian, homeostatic, and REM-pressure drives into the model.Dynamical analysis using a potential-landscape theory and linear stability analysis reveals multiple stable attractors corresponding to wake, NREM, and REM states.This framework clarifies how parameter variations reshape transition thresholds. Notably, wake maintenance is enhanced by reciprocal arousal-action excitation, which also constrains direct WaketoREM transitions. In contrast, the NREM-REM cycle appears largely insensitive to reciprocal arousal-action excitation, indicating a modular separation between wake stability and the core NREM-REM oscillator. Our formulation reproduces key features of human sleep architecture, including robust NREM-REM ultradian cycling (~90 minutes) embedded within a broader ~24-hour sleep–wake rhythm, with realistic transition sequences and hysteresis between states.The framework offers a versatile, testable platform for exploring sleep regulation, with potential translational relevance to insomnia, hypersomnia, REM sleep disorders, and chronotherapy.